These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Design and evaluation of temperature-responsive chitosan/hydroxypropyl cellulose blend nanospheres for sustainable flurbiprofen release.
    Author: Işıklan N, Erol ÜH.
    Journal: Int J Biol Macromol; 2020 Sep 15; 159():751-762. PubMed ID: 32416307.
    Abstract:
    In present work, temperature-responsive flurbiprofen (FLU) containing chitosan/hydroxypropyl cellulose (CS/HPC) blend nanospheres were prepared using emulsion method. The structures of blend nanospheres were characterized by ATR-FTIR, XRD, SEM, DSC/TGA, zeta potential and particle size analyses. Their lower critical solution temperatures (LCST) were determined and found to be 42 °C. In vitro release studies were performed in gastrointestinal-tract simulated conditions at 30 °C, 37 °C and 44 °C. As the medium temperature was increased, the release of FLU decreased, indicating that blend nanospheres had temperature-responsive feature. The FLU release demonstrated that release profiles depend upon CS/HPC ratio, amount of FLU present in the nanospheres and percentage of cross-linker used. Moreover, the cytotoxicity tests were performed via MTT method and it was observed CS/HPC nanospheres were biocompatible. Based on the in vitro release profile and cytotoxicity studies, the fabricated CS/HPC blend nanospheres could be a promising candidate as a temperature-responsive nano-carrier for controlled drug release.
    [Abstract] [Full Text] [Related] [New Search]