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  • Title: Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Acyclic α-N-Pyrrolyl/Indolyl Ketones.
    Author: Lavernhe R, Alexy EJ, Zhang H, Stoltz BM.
    Journal: Org Lett; 2020 Jun 05; 22(11):4272-4275. PubMed ID: 32422045.
    Abstract:
    The synthesis of fully substituted α-N-pyrrolyl and indolyl ketones via enantioselective palladium-catalyzed allylic alkylation is described. The acyclic ketones are alkylated in high yields with high enantioselectivities through the use of an electron-deficient phosphinooxazoline ligand, furnishing a highly congested and synthetically challenging stereocenter. The obtained alkylation products contain multiple reactive sites poised for additional functionalizations and diversification.
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