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  • Title: Relationship between PET metabolism and SEEG epileptogenicity in focal lesional epilepsy.
    Author: Lagarde S, Boucekine M, McGonigal A, Carron R, Scavarda D, Trebuchon A, Milh M, Boyer L, Bartolomei F, Guedj E.
    Journal: Eur J Nucl Med Mol Imaging; 2020 Dec; 47(13):3130-3142. PubMed ID: 32430581.
    Abstract:
    PURPOSE: This study aims to evaluate the performance of 18F-FDG PET for distinguishing the epileptogenic zone (EZ) from propagation and non-involved zones at brain area level, as defined using stereo-EEG (SEEG), in patients with pharmacoresistant epilepsy due to malformations of cortical development (MCD). Additionally, we seek to determine the relationship between 18F-FDG-PET data and post-surgical seizure outcome. METHODS: Thirty-eight patients with MCD were explored with 18F-FDG PET and SEEG. We compared PET metabolism of each patient to a control population of healthy subjects. Based on MRI and SEEG, we separated 4 distinct zones at individual level: lesional, epileptogenic non-lesional, propagation, and non-involved. Then, we analysed (1) difference of PET metabolism within these four distinct zones; (2) performance of PET in defining the EZ within the SEEG-sampled areas; and (3) relation between extension of PET hypometabolism and post-surgical seizure outcome. RESULTS: We found (1) a gradient of PET hypometabolism from non-involved to propagation, then to epileptogenic and lesional zones (p < 0.001); (2) good performance of PET in defining the EZ (AUC of ROC curve = 0.82); (3) poorer post-surgical prognosis associated with PET hypometabolism extension beyond SEEG sampling (p = 0.024). CONCLUSION: 18F-FDG-PET has good accuracy in determining EZ in patients with MCD even if the hypometabolism is not limited to the EZ. Furthermore, hypometabolic extension is unfavourably associated with post-surgical prognosis.
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