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  • Title: Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives.
    Author: Gracheva IA, Shchegravina ES, Schmalz HG, Beletskaya IP, Fedorov AY.
    Journal: J Med Chem; 2020 Oct 08; 63(19):10618-10651. PubMed ID: 32432867.
    Abstract:
    Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its pharmacological potential as a lead structure is not yet fully exploited. This review is devoted to the synthesis and structure-activity relationships (SAR) of colchicine alkaloids and their analogues with modified A, B, and C rings, as well as hybrid compounds derived from colchicinoids including prodrugs, conjugates, and delivery systems. The systematization of a vast amount of information presented to date will create a paradigm for future studies of colchicinoids for neoplastic and various other diseases.
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