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  • Title: Valinomycin-induced chloride permeability in isolated rat liver mitochondria.
    Author: Schnell FC, Moreland DE.
    Journal: Int J Biochem; 1988; 20(12):1361-8. PubMed ID: 3243376.
    Abstract:
    1. Ionophore-induced osmotic swelling was used to study Cl- transport in isolated rat liver mitochondria. 2. Energy-dependent, neutral ionophore-induced swelling in Cl- salts at pH 7.2 required K+ and was preceded by a brief lag phase that was absent in chlorotributyltin-induced swelling. 3. Treatments that stimulated or inhibited mitochondrial K+/H+ exchange had qualitatively similar effects on both valinomycin-induced swelling and the associated lag phase. 4. The results suggest that valinomycin-induced Cl- permeability results from an interaction between the K+/H+ antiporter and neutral ionophore K+ complexes.
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