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  • Title: Interaction of Sr2+ with Ca2+-induced Ca2+ release in mitochondria.
    Author: Saris NE, van den Bosch H.
    Journal: J Bioenerg Biomembr; 1988 Dec; 20(6):749-57. PubMed ID: 3243774.
    Abstract:
    Respiring rat liver mitochondria are known to spontaneously release the Ca2+ taken up when they have accumulated Ca2+ over a certain threshold, while Sr2+ and Mn2+ are well tolerated and retained. We have studied the interaction of Sr2+ with Ca2+ release. When Sr2+ was added to respiring mitochondria simultaneously with or soon after the addition of Ca2+, the release was potently inhibited or reversed. On the other hand, when Sr2+ was added before Ca2+, the release was stimulated. Ca2+-induced mitochondrial damage and release of accumulated Ca2+ is generally believed to be due to activation of mitochondrial phospholipase A (EC 3.1.1.4.) by Ca2+. However, isolated mitochondrial phospholipase A activity was little if at all inhibited by Sr2+. The Ca2+-release may thus be triggered by some Ca2+-dependent function other than phospholipase.
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