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  • Title: [Effect of the peroral use of the antitumor antibiotic, carminomycin, on the immunological reactivity of the body of animals].
    Author: Shapovalova SP, Malkova IV.
    Journal: Antibiotiki; 1977; 22(2):168-72. PubMed ID: 324385.
    Abstract:
    Carminomycin administered orally to mice for many times in doses of 2.5 and 1.25 mg/kg induced suppression of hemagglutinine production to sheep erythrocytes and formation of immunologically competent cells in the spleen of test animals. The content of DNA and RNA in the spleen of the test animals treated with carminomycin and sheep erythrocytes was somewhat lower than that in the control mice immunized but not treated with the antibiotic. Carminomycin prolongated the life time of the skin graft by 6.5 days as compared to that of the skin homotransplant in the control animals. The oral use of carminomycin in a dose of 2.5 mg/kg induced a statistically significant decrease in the absorption capacity of the cells of the reticuloendothelial system of the animals.
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