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  • Title: New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens.
    Author: Hou JQ, Zhao H, Yu JH, Chen LJ, Wang H.
    Journal: Chin J Nat Med; 2020 May; 18(5):379-384. PubMed ID: 32451095.
    Abstract:
    Phytochemical investigation of the aerial parts of Baeckea frutescens resulted in the isolation of three new mono- or sesquiterpene-based meroterpenoids, frutescones S-U (1-3), and one pair of new (±)-5,7-dihydroxy-8-isobutyryl-6-methyldihydroflavonol (4). Their structures and absolute configurations were established by HR-ESI-MS, 1D and 2D NMR, and quantum chemical ECD calculation. Compound 1 exhibited inhibitory effect on NO production in LPS-activated RAW 264.7 macrophages with an IC50 value being 0.81 μmol·L-1.
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