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  • Title: Blended effects of herbal components of tokishakuyakusan on rat corpus luteum function in vivo.
    Author: Usuki S.
    Journal: Am J Chin Med; 1988; 16(3-4):107-16. PubMed ID: 3245532.
    Abstract:
    The effect of herbal components of Tokishakuyakusan on progestin levels in serum and ovarian tissue from rats treated with PMS and hCG was examined in vivo. Hoelen + peony root + Japanese angelica root increased progesterone/20 alpha-OHP ratio in serum, and hoelen or peony root also increased the ratio in ovarian tissue, while atractylodes lanceae rhizome or hoelen + atractylodes lanceae rhizome decreased the ratio in serum and ovarian tissue. These data suggested that hoelen or peony root has a luteotropic effect but that atractylodes lanceae rhizome develops luteolysis. Furthermore, the data indicated a blended effect of herbal components of Tokishakuyakusan on the corpus luteum.
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