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  • Title: Age-dependent changes in the level of a 22 KDa plasma membrane phosphoprotein in developing chick embryo brain.
    Author: David E, Shanmugam G.
    Journal: Biochem Int; 1988 Dec; 17(6):1039-47. PubMed ID: 3245837.
    Abstract:
    In vitro phosphorylation of brain proteins of developing chick embryos showed a drastic increase in the extent of phosphorylation of a 22 KDa protein from the fourteenth day reaching a peak at seventeenth day of development; the phosphorylation of the 22 KDa protein declined afterwards. Phosphoaminoacid analysis of the 22 KDa protein indicated serine residues as targets of phosphorylation. Isoelectric focusing followed by second dimensional SDS-PAGE indicated that the 22 KDa protein had a pI value of 4.5. Polymyxin B, an inhibitor of Ca2+ and phospholipid dependent protein kinases inhibited the phosphorylation of the 22 KDa protein.
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