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  • Title: The influence of exogenous pituitary growth hormone on the ovulatory response to PMSG and hCG and the LH response to estradiol benzoate in prepubertal gilts.
    Author: Kirkwood RN, Thacker PA, Korchinski RS, Laarveld B.
    Journal: Domest Anim Endocrinol; 1988 Oct; 5(4):317-22. PubMed ID: 3246148.
    Abstract:
    Two experiments were performed to examine the influence of exogenous growth hormone on the reproductive axis in gilts. Experiment one employed 26 Yorkshire X Landrace prepubertal gilts, which were selected at 150 d and 86.5 +/- 1.5 kg bodyweight (BW) and assigned equally to two treatments. Gilts received injections of either porcine growth hormone at 90 micrograms/kg BW, or vehicle buffer, from 150 to 159 d. At 154 d gilts received 500 IU PMSG, followed 96 hr later by 250 IU hCG. Gilts were slaughtered at 163 days and their ovaries recovered to determine ovulatory status. In each treatment, 2/13 gilts failed to show any ovarian response to PMSG/hCG. All remaining control gilts ovulated and their ovaries appeared morphologically normal. In gilts receiving exogenous growth hormone, fewer ovaries (4/11, P less than .01) appeared morphologically normal. The ovaries of all other growth hormone injected gilts had very large (12-25 mm) non-luteinized follicles. In experiment two, 20 prepubertal Yorkshire X Landrace gilts were selected at 138 days and 85 kg BW. These gilts received injections of growth hormone at 90 micrograms/kg BW (n = 9) or vehicle (n = 11) from 138 to 147 days. At 143 days, all gilts were given an injection of estradiol benzoate (EB) at 15 micrograms/kg BW. Blood samples were taken at the time of EB injection, at 24 and 36 hr and then at 6 hr intervals until 78 hr. All samples were assayed for serum LH concentrations. The EB induced LH peak height was lower (P less than .04) in gilts receiving exogenous growth hormone than in controls.(ABSTRACT TRUNCATED AT 250 WORDS)
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