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  • Title: Evaluation of single-drug versus multiple-drug chemotherapy in the treatment of advanced breast cancer.
    Author: Mouridsen HT, Palshof T, Brahm M, Rahbek I.
    Journal: Cancer Treat Rep; 1977; 61(1):47-50. PubMed ID: 324620.
    Abstract:
    Fifty-one postmenopausal patients with advanced breast cancer were randomized to receive either cyclophosphamide given continuously or cyclophosphamide given continuously with methotrexate, 5-fluorouracil, vincristine, and prednisone given intermittently. The results with the multiple-drug therapy were significantly better than with the single-drug therapy, both with regard to percentage (63% versus 25%) and median duration (400 versus 210 days) of objective response. Toxicity was moderately increased with the combination as compared to the single-drug treatment.
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