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  • Title: Type I collagen matrix plus polyhexamethylene biguanide antimicrobial for the treatment of cutaneous wounds.
    Author: Bain MA, Koullias GJ, Morse K, Wendling S, Sabolinski ML.
    Journal: J Comp Eff Res; 2020 Jul; 9(10):691-703. PubMed ID: 32476449.
    Abstract:
    Aim: Determine the effectiveness of purified native type I collagen matrix plus polyhexamethylene biguanide antimicrobial (PCMP) on cutaneous wounds. Materials & methods: A prospective cohort study of 307 patients (67 venous leg ulcers, 62 diabetic foot ulcers, 45 pressure ulcers, 54 post-surgical wounds and 79 other wounds) was conducted. Results: Cox wound closure for PCMP was 73% at week 32. The median time to wound closure was 17 weeks (Kaplan-Meier). The incidence of PCMP-treated wounds showing >60% reductions in areas, depths and volumes were 81, 71 and 85%, respectively. Conclusion: PCMP demonstrated clinically meaningful benefits to patients with various types of cutaneous wounds. Clinical Trial registration number: NCT03286452.
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