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  • Title: Endothelium-dependent relaxant effect of thrombin on isolated pig coronary arteries.
    Author: Glusa E.
    Journal: Biomed Biochim Acta; 1988; 47(10-11):S67-70. PubMed ID: 3248118.
    Abstract:
    In pig coronary arteries with intact endothelium the clotting enzyme thrombin at physiologically relevant concentrations caused a reversible transient and concentration-dependent relaxation of PGF2 alpha-precontracted vessels which was absent in case of mechanically removed endothelium. The thrombin-induced relaxation was not affected by indomethacin. Exposure of the coronary arteries to a calcium-free medium or preincubation with verapamil led to the reduction of the PGF2 alpha-induced contraction while the relaxant effect of thrombin was only slightly inhibited. However, the guanylate cyclase inhibitor methylene blue diminished the relaxant response to thrombin. The specific tight-binding thrombin inhibitor hirudin prevented the relaxant effect of thrombin in a concentration-dependent manner.
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