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  • Title: Assessment of pituitary response to nasal application of synthetic gonadotropin-releasing hormone in men.
    Author: Potashnik G, Ben-Adereth N, Lunenfeld B, Rofe C.
    Journal: Fertil Steril; 1977 Jun; 28(6):650-4. PubMed ID: 324823.
    Abstract:
    An attempt has been made to assess the pituitary response to the nasal application of synthetic gonadotropin-releasing hormone (GnRH) in three oligospermic and two azoospermic men. Intranasal administration of 3 mg of GnRH in aqueous or natural plant gum solution produced a pituitary response pattern similar to that produced by the intramuscular injection of 100 microng, with respect to plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). No technical difficulties or side effects were observed. GnRH in a nasal drop preparation seems to be effective in releasing LH and FSH in men. These findings may have a practical application in those cases where long-term therapy with the hormone is indicated.
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