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  • Title: Sodium dependence of early distal H+ secretion in rat kidney.
    Author: Lopes MJ, Malnic G.
    Journal: Braz J Med Biol Res; 1988; 21(5):1065-8. PubMed ID: 3248235.
    Abstract:
    In order to study the mechanism of H-ion secretion in cortical distal tubules of the rat kidney, the luminal pH and transepithelial potential difference (PD) were measured with double-barrelled, pH-sensitive, resin/reference microelectrodes. Perfusion of peritubular capillaries with low-sodium solutions increased luminal pH by 0.28 +/- 0.024 units. Perfusion of the lumen with 1 mM amiloride increased luminal pH by 0.67 +/- 0.01 units. These changes could not be attributed to modification of transepithelial PD. We conclude that early distal acidification is sodium-dependent, possibly owing to the presence of Na+/H+ exchange.
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