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  • Title: [Papilloma of forestomach induced by Fusarium T-2 toxin in mice].
    Author: Yang S.
    Journal: Zhonghua Zhong Liu Za Zhi; 1988 Sep; 10(5):339-41. PubMed ID: 3248499.
    Abstract:
    T-2 toxin is one of the important representatives of trichothecin metabolites of Fusarium species. Various proliferative changes in epithelia of forestomach including papillomas were induced in mice after prolonged feeding of T-2 toxin by intubation at 0.1 mg/kg, 3 times a week for 25 weeks. The incidences of hyperkeratosis, papillary hyperplasia, moderate dysplasia and papilloma were 82.9%, 28.6%, 42.9% and 14.3% respectively. The earliest papilloma in forestomach of mice occurred as early as 6th week of the experiment. While in forestomach of mice in the control group, only 4.20% hyperkeratosis and 4.2% simple hyperplasia were found, no papillary hyperplasia or papilloma occurred. The above results indicate that T-2 toxin has a selective tumorigenic effect on the forestomach which is actually the extension of the esophagus in mice. These findings may give important hint to the study of human esophageal carcinogenesis.
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