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  • Title: Leydig cell insufficiency after testicular irradiation for acute lymphoblastic leukemia.
    Author: Brauner R, Caltabiano P, Rappaport R, Leverger G, Schaison G.
    Journal: Horm Res; 1988; 30(2-3):111-4. PubMed ID: 3248774.
    Abstract:
    Leydig cell function in 21 boys with acute lymphoblastic leukemia who had been treated by bilateral direct testicular irradiation (12 X 2 Gy) at 8.4 +/- 0.7 years, was evaluated 3.8 +/- 0.4 years after irradiation. At the time of irradiation all were prepubertal and at evaluation 12 were prepubertal and 9 pubertal. Leydig cell insufficiency, indicated by a low plasma testosterone response to chorionic gonadotrophin and/or an increase in basal level of plasma luteinizing hormone, was observed in 19/21 patients. The children who were the youngest at testicular irradiation were more vulnerable. Spontaneous virilization occurred in 3 of the older children and resulted from compensated Leydig cell dysfunction.
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