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  • Title: All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery.
    Author: Costa C, Liu Z, Martins JP, Correia A, Figueiredo P, Rahikkala A, Li W, Seitsonen J, Ruokolainen J, Hirvonen SP, Aguiar-Ricardo A, Corvo ML, Santos HA.
    Journal: Biomater Sci; 2020 Jun 21; 8(12):3270-3277. PubMed ID: 32490443.
    Abstract:
    Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
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