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  • Title: In vitro susceptibility of cephalothin-resistant Enterobacteriaceae to cefoxitin and BL-S786.
    Author: Meyer RD.
    Journal: J Antibiot (Tokyo); 1977 Apr; 30(4):326-9. PubMed ID: 324961.
    Abstract:
    The in vitro antibacterial activity of two agents relatively resistant to beta-lactamases, BL-S786 and cefoxitin, was tested against 123 recent different clinical isolates of cephalothin-resistant Enterobacteriaceae. BL-S786 showed considerable activity against Escherichia coli and lesser activity against Klebsiella pneumoniae with, respectively, 68% and 41% inhibited at 32 microng/ml. Cefoxitin showed more activity in vitro against E. coli, K. pneumoniae, Serratia marcescens and Providencia stuartii. Cefoxitin appears to be a more promising agent for treating infections caused by cephalothin-resistant Enterobacteriaceae.
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