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  • Title: One-Pot Tandem Michael Addition/Enantioselective Conia-Ene Cyclization Mediated by Chiral Iron(III)/Silver(I) Cooperative Catalysis.
    Author: Horibe T, Sakakibara M, Hiramatsu R, Takeda K, Ishihara K.
    Journal: Angew Chem Int Ed Engl; 2020 Sep 14; 59(38):16470-16474. PubMed ID: 32500562.
    Abstract:
    The first one-pot tandem Michael addition/enantioselective Conia-ene cyclization of N-protected prop-2-yn-1-amines with 2-methylene-3-oxoalkanoates promoted by chiral iron(III)/silver(I) cooperative catalysts has been developed. Alkyl 4-methylenepyrrolidine-3-acyl-3-carboxylates, which can be transformed into β-proline derivatives, are obtained in high yield with high enantioselectivity.
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