These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide.
    Author: Silva E, Higgins M, Hammer B, Stephenson P.
    Journal: BMC Psychiatry; 2020 Jun 05; 20(1):279. PubMed ID: 32503471.
    Abstract:
    Clozapine remains the only drug treatment likely to benefit patients with treatment resistant schizophrenia. Its use is complicated by an increased risk of neutropenia and so there are stringent monitoring requirements and restrictions in those with previous neutropenia from any cause or from clozapine in particular. Despite these difficulties clozapine may yet be used following neutropenia, albeit with caution. Having had involvement with 14 cases of clozapine use in these circumstances we set out our approach to the assessment of risks and benefits, risk mitigation and monitoring with a practical guide.
    [Abstract] [Full Text] [Related] [New Search]