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  • Title: Experimental carbon tetrachloride-induced cirrhosis of the liver.
    Author: Muñoz Torres E, Paz Bouza JI, Abad Hernandez MM, Alonso Martin MJ, Lopez Bravo A.
    Journal: Int J Tissue React; 1988; 10(4):245-51. PubMed ID: 3250938.
    Abstract:
    The authors produced an experimental model of cirrhosis by administering carbon tetrachloride (CCl4) intraperitoneally over 46 weeks to female Wistar rats at a dose of 0.2 ml of a solution of CCl4 in 33% mineral oil. The cytotoxic effect on the liver of this substance was evaluated in different developmental stages of the process by macroscopic, microscopic and ultrastructural studies.
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