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  • Title: Antifungal activity of 5-fluorocytosine as measured by disk diffusion susceptibility testing.
    Author: Utz CJ, Shadomy S.
    Journal: J Infect Dis; 1977 Jun; 135(6):970-4. PubMed ID: 325150.
    Abstract:
    The susceptibilities of 216 isolates of pathogenic and commensal yeasts to 5-fluorocytosine were tested by a disk diffusion technique with use of 1- and 10-microgram disks. Minimal inhibitory concentrations (MICs) were determined by an agar dilution procedure with yeast morphology agar, pH 5.0, supplemented with 0.25 mg of thiamine/dl. Zones of inhibition produced by the two disks were correlated with paired MIC values. An MIC of 16 micrograms/ml, the upper limit of probable clinical susceptibility, correlated with zones of 14 mm and 25 mm, respectively, for the 1- and 10-microgram disks. With these values as interpretative breakpoints, the 1-microgram disk would have failed to predict clinical susceptibility with 25% of the suceptible isolates of Candida species other than Candida albicans, with 14% of the susceptible isolates of Cryptococcus neoformans, with 7% of the susceptible isolates of C. albicans, and with one of the 25 susceptible isolates of Torulopsis glabrata. The 10-microgram disk would have failed to predict susceptibility with only two isolates of Candida species.
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