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  • Title: Acyl derivatives of 1,5-benzodiazepines. III. Acyl derivatives of ethyl ester of 4-methyl-1H-tetrahydro-1,5-benzodiazepine-2-carboxylic acid.
    Author: Nawojski A, Nawrocka W, Liszkiewicz H, Wilimowski M, Barczyńska J, Kedzierska L, Wojewódzki W, Rutkowska M, Duś E, Szelag A.
    Journal: Pol J Pharmacol Pharm; 1988; 40(5):471-80. PubMed ID: 3253716.
    Abstract:
    Two series of derivatives of ethyl ester of 4-methyl-1H-tetrahydro-1,5-benzodiazepine-2-carboxylic acid (1) have been synthesized. The acetyl derivative (2) of ester 1 in preliminary pharmacological screening showed analgesic activity in the "writhing" test and the benzoyl derivative (5) exhibited antianxiety properties in the four plate test, while N,N-disubstituted aminoacetyl derivatives of 1 showed analgesic and anticonvulsant activity (10).
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