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  • Title: Radiolabeled porphyrin vs gallium-67 citrate for the detection of human melanoma in athymic mice.
    Author: Maric N, Chan SM, Hoffer PB, Duray P.
    Journal: Int J Rad Appl Instrum B; 1988; 15(5):543-51. PubMed ID: 3254877.
    Abstract:
    We performed the biodistribution and imaging studies of 111In and 67Ga labeled tetra(4-N-methylpyridyl)porphine, (T4NMPYP), and compared it to that of 67Ga-citrate in athymic mice bearing a human melanoma xenograft. The biodistribution results of both 111In and 67Ga labeled T4NMPYP (3, 6, 24 and 48 h) were similar but differed from that of 67Ga-citrate (48 h). The optimum tumor uptake of both radiolabeled porphyrins was at 6 h post-injection and was lower than the tumor uptake of 67Ga-citrate at 48 h post-injection. Kidney was the only organ showing higher uptake of radiolabeled porphyrin compared to that of 67Ga-citrate. The imaging studies performed with 111In-T4NMPYP and 67Ga-citrate correspond to the biodistribution results. Osteomyelitis present in one mouse showed good localization of 111In-T4NMPYP.
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