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  • Title: [Expression and Significance of PD-1, TIM-3 and VISTA on T Cell of Acute Myeloid Leukemia Patients].
    Author: Ge MJ, Xu KL, Xu T, Tang YN, Li ZY, Yan ZL, Sun HY, Cheng H, Zhu F, Sang W, Huang YH, Qiu TT, Li DP.
    Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2020 Jun; 28(3):748-752. PubMed ID: 32552931.
    Abstract:
    OBJECTIVE: To study the expression of multiple negative costimulatory molecules on peripheral blood T cells in patients with acute myeloid leukemia (AML) and its affection on prognosis. METHODS: The peripheral blood samples from patients with newly diagnosed AML, complete remission (CR), and no-remission (NR) were collected, the expression levels PD-1、VISTA and TIM-3 in CD4+ and CD8+ T cells were detected by flow cytometry , and the clinical data of patients were analyzed. RESULTS: The expression levels of PD-1、VISTA and TIM-3 of CD4+ and CD8+ T cells in the newly diagnosed AML patients were significantly higher than those in control group (P＜0.05). The expression levels of PD-1、TIM-3 and VISTA of CD4+ and CD8+ T cells in the CR group were significantly lower than those in newly diagnosed and the NR group (P＜0.05). The TIM-3 expression level positively correlated with VISTA expression level of CD4+ and CD8+ T cells in newly diagnosed AML patients (r=0.85 and 0.73). The VISTA and PD-1 expression level of CD4+ T cells in newly diagnosed AML, NR after first induction chemotherapy and high risk patients significantly increased (P＜0.05), the TIM-3 expression level of CD8+ T cells in high risk group significantly increased (P＜0.05), and the VISTA expression level of CD8+ T cells in CBFβ-MYH11 mutation-positive group significantly decreased (P＜0.05). CONCLUSION: The expression of PD-1、TIM-3 and VISTA in AML peripheral blood T cells may be involved in the immune escape of AML and can be the targets of treatment for acute myeloid leukemia patients. 题目: PD-1、TIM-3、VISTA在急性髓系白血病患者T细胞上的表达及意义. 目的: 研究多种负性共刺激分子在急性髓系白血病（AML）患者外周血T细胞上的表达及其对预后的影响. 方法: 收集初治、完全缓解（CR）、未缓解（NR）AML患者外周血标本，采用流式细胞术检测CD4+和CD8+ T细胞PD-1、VISTA、TIM-3的表达水平，并收集患者临床资料进行统计分析. 结果: 初治AML组患者CD4+和CD8+ T 细胞PD-1、VISTA、TIM-3表达水平均较对照组显著增高（P＜0.05），CR组CD4+和CD8+T细胞PD-1、TIM-3、 VISTA表达水平均较初治组及NR组显著降低（P＜0.05）；初治AML患者CD4+ 和CD8+ T细胞TIM-3表达水平与VISTA表达水平正相关（r=0.85，r=0.73）；初治AML患者，首次诱导化疗未缓解组及高危组患者CD4+ T细胞PD-1、VISTA表达水平显著上升（P＜0.05），高危组CD8+ T细胞TIM-3表达水平显著上升（P＜0.05），CBFβ-MYH11突变阳性组CD8+ T细胞VISTA表达水平显著降低（P＜0.05）. 结论: PD-1、TIM-3、VISTA在AML外周血T细胞上的表达可能参与AML的免疫逃逸，并可能成为急性髓系白血病患者的治疗靶点.
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