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  • Title: Comparison of the biodistribution of 153Gd-labeled Gd(DTPA)2-, Gd(DOTA)-, and Gd(acetate)n in mice.
    Author: Wedeking P, Tweedle M.
    Journal: Int J Rad Appl Instrum B; 1988; 15(4):395-402. PubMed ID: 3255735.
    Abstract:
    The biodistributions of 153Gd-labeled Gd(DTPA)2-, Gd(DOTA)-, and Gd(acetate)n were determined in mice at five residence times. Gd(DTPA)2- and Gd(DOTA)- had similar distributions with greater than 89% renally excreted in 1 h. At 7 days and longer after Gd(DTPA)2- administration, 153Gd bone levels were higher than could be attributed to free 153Gd3+, suggesting that Gd(DTPA)2- dechelates in vivo. Gd(DOTA)- did not appear to dechelate. Gd(acetate)n did not readily clear and 153Gd levels remained high in liver, lungs, and spleen for 28 days.
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