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  • Title: Applications of magnetotactic bacteria and magnetosome for cancer treatment: A review emphasizing on practical and mechanistic aspects.
    Author: Alphandéry E.
    Journal: Drug Discov Today; 2020 Aug; 25(8):1444-1452. PubMed ID: 32561298.
    Abstract:
    Magnetotactic bacteria (MTB) synthesize iron oxide (Fe3O4) nanoparticles (NPs), called magnetosomes, with large sizes leading to a ferrimagnetic behavior and a stable magnetic moment at physiological temperature, a chain structure that prevents NP aggregation and promotes uniform NP distribution, and a mineral core of magnetite/maghemite composition, which can be stabilized by an organic coating. Such properties can favor magnetosome administration to humans under certain optimized non-toxic conditions of fabrication. In this review, I describe the fabrication methods, physico-chemical properties, and the anti-tumor activity of different types of MTB/magnetosome preparations, highlighting the bio-compatibility and excellent anti-tumor activity of purified non-pyrogenic magnetosome minerals stabilized by a synthetic chemical compound.
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