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  • Title: Design, Synthesis and in Vitro Evaluation of Tylophorine Derivatives as Possible Antitumor Agents.
    Author: Mang Z, Zhang S, Bai J, Li M, Li H.
    Journal: Chem Biodivers; 2020 Sep; 17(9):e2000066. PubMed ID: 32567792.
    Abstract:
    Structural simplification and modification of natural products are always very important resources to antitumor drugs. By introducing various aminomethyl groups and amide groups into the phenanthrene ring of tylophorine, a novel series of tylophorine derivatives have been designed and synthesized, and their antiproliferative activities against MCF-7, A549 and HepG-2 cells have been evaluated, too. The results indicated that most of the prepared compounds exhibited good antitumor activities. Especially, one compound with an {ethyl[2-(morpholin-4-yl)ethyl]amino}methyl group at the side chain exhibited the most significant cytotoxic effects.
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