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  • Title: Anti-Leu-3a antibody reactivity with Reed-Sternberg cells of Hodgkin's disease.
    Author: Oka K, Mori N, Kojima M.
    Journal: Arch Pathol Lab Med; 1988 Feb; 112(2):139-42. PubMed ID: 3257383.
    Abstract:
    Eleven cases of Hodgkin's disease were studied using ten monoclonal antibodies. Our findings indicated that Reed-Sternberg cells and Hodgkin's cells were distinctly stained for HLA-DR and LN-2 in all the cases, for Leu-3a in six cases, and for Leu-M1 in eight cases. They were not stained for Leu-1, Leu-2a, Leu-4, OKT3, OKT6, or LN-1 in any of the cases. Although these results remain insufficient to find any conclusions concerning the nature of Reed-Sternberg cells and Hodgkin's cells, Leu-3a reactivity may represent the aberrant form of T-cell phenotype. Alternatively, we suggest that Reed-Sternberg cells and Hodgkin's cells may be derived from monocyte-macrophage lineage because normal and neoplastic cells of monocyte/macrophage lineage express Pan-T antigen-/HLA-DR+/Leu-3a+/OKT6- phenotype.
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