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Title: The Interplay between Adeno-Associated Virus and its Helper Viruses. Author: Meier AF, Fraefel C, Seyffert M. Journal: Viruses; 2020 Jun 19; 12(6):. PubMed ID: 32575422. Abstract: The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.[Abstract] [Full Text] [Related] [New Search]