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  • Title: DNA content of T-cell lymphomas. A flow-cytometric analysis.
    Author: Egerter DA, Said JW, Epling S, Lee S.
    Journal: Am J Pathol; 1988 Feb; 130(2):326-34. PubMed ID: 3257649.
    Abstract:
    Paraffin-embedded archival tissue from 29 cases of malignant non-Hodgkin's lymphoma of T-cell type and 9 control lymph nodes were examined by flow cytometry for DNA aneuploidy and cell-cycle kinetics. DNA aneuploidy was detected in 4 cases (13%) and was not related to histologic grade. Proliferative activity, as measured by proliferative index and S-phase fraction, was significantly increased in lymphomas, compared with controls, and was significantly higher in morphologically high-grade lymphomas, compared with low-grade lymphomas and control lymph nodes (P less than 0.05). Different morphologic types of T-cell lymphoma were also significantly different in their proliferative activity P less than 0.05). Moreover, within the category of peripheral T-cell lymphoma, different proliferative rates occurred in tumors in which small cells predominated, compared with intermediate- and large-cell tumors, suggesting biologic differences within this group.
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