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Title: An octabrominated Sn(iv) tetraisopropylporphyrin as a photosensitizer dye for singlet oxygen biomedical applications. Author: Babu B, Mack J, Nyokong T. Journal: Dalton Trans; 2020 Jul 21; 49(28):9568-9573. PubMed ID: 32578634. Abstract: Two novel Sn(iv) tetraisopropylphenylporphyrins have been synthesized to explore the effect of octabromination at the β-pyrrole positions on their photophysical properties and photodynamic activity. The lower energy Q band of an octabrominated complex lies at 675 nm well within the therapeutic window. The octabrominated dye has a relatively high singlet oxygen quantum yield of 0.78 in DMF and exhibits favorable photodynamic activity against MCF-7 cells with an IC50 value of 10.7 μM and a 5.74 log reduction value (5 μM) towards S. aureus under illumination at 660 nm for 60 min with a Thorlabs M660L3 LED (280 mW cm-2).[Abstract] [Full Text] [Related] [New Search]