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  • Title: Transfusion-induced specific anti-factor XI inhibitor in a patient with previously unrecognized factor XI deficiency.
    Author: Musclow CE, Amato D, Ofosu F, Armstrong AL, Abbott D.
    Journal: Am J Clin Pathol; 1988 Mar; 89(3):418-22. PubMed ID: 3258118.
    Abstract:
    This article reports the rare occurrence and investigation of a specific anti-factor XI inhibitor that arose after fresh-frozen plasma infusion into a patient with previously unrecognized Factor XI deficiency. The IgG fraction of the patient's plasma that contained anti-Factor XI antibody was isolated by chromatography on DEAE-Affigel and concentrated. It was shown to exert inhibitory effect on purified Factor XI and XIa both in the activated and nonactivated partial thromboplastin time assay.
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