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  • Title: Potassium-free solution prevents the action but not the release of endothelium-derived relaxing factor.
    Author: Rubanyi GM, Vanhoutte PM.
    Journal: Eur J Pharmacol; 1988 Jan 19; 145(3):351-5. PubMed ID: 3258243.
    Abstract:
    Exposure to a K+-free solution reversibly inhibited the acetylcholine-induced relaxation in perfused canine femoral artery segments with endothelium and in superfused bioassay femoral artery rings without endothelium. Infusion of 6.7 mM K+ into the K+-free perfusate downstream of the perfused artery restored the acetylcholine-induced relaxation in the bioassay ring, whereas no relaxation was observed in the perfused segment still exposed to the K+-free solution. These data demonstrate that the K+-free solution depresses the endothelium-dependent relaxation to acetylcholine in femoral arteries by preventing the action, but not the production, of endothelium-derived relaxing factor.
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