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  • Title: CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF PATIENTS DIAGNOSED WITH COVID-19 IN A TERTIARY CARE CENTER IN MEXICO CITY: A PROSPECTIVE COHORT STUDY.
    Author: Ortiz-Brizuela E, Villanueva-Reza M, González-Lara MF, Tamez-Torres KM, Román-Montes CM, Díaz-Mejía BA, Pérez-García E, Olivas-Martínez A, Rajme-López S, Martinez-Guerra BA, de-León-Cividanes NA, Fernández-García OA, Guerrero-Torres L, Torres-González L, Carrera-Patiño FA, Corral-Herrera EA, Hernández-Alemón AN, Tovar-Vargas MLÁ, Serrano-Pinto YG, Espejo-Ortiz CE, Morales-Ortega ML, Lozano-Cruz ÓA, Cárdenas-Fragoso JL, Vidal-Mayo JJ, Hernández-Gilsoul T, Rivero-Sigarroa E, Domínguez-Cherit G, Cervantes-Villar LE, Ramos-Cervantes MDP, Ibarra-González V, Calva-Mercado JJ, Sierra-Madero JG, López-Íñiguez Á, Ochoa-Hein E, Crabtree-Ramírez BE, Galindo-Fraga A, Guerrero-Almeida ML, Ruiz-Palacios GM, Gulías-Herrero A, Sifuentes-Osornio J, Kershenobich-Stalnikowitz D, Ponce-de-León A.
    Journal: Rev Invest Clin; 2020; 72(3):165-177. PubMed ID: 32584326.
    Abstract:
    BACKGROUND: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding of the pandemic. OBJECTIVE: The objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC). METHODS: We conducted a prospective cohort, including consecutive patients with COVID-19 from February 26, 2020 to April 11, 2020. RESULTS: We identified 309 patients (140 inpatients and 169 outpatients). The median age was 43 years (interquartile range, 33-54), 59.2% men, and 18.6% healthcare workers (12.3% from our center). The median body mass index (BMI) was 29.00 kg/m2 and 39.6% had obesity. Compared to outpatients, inpatients were older, had comorbidities, cough, and dyspnea more frequently. Twenty-nine (20.7%) inpatients required treatment in the IC unit (ICU). History of diabetes (type 1 or 2) and abdominal pain were more common in ICU patients compared to non-ICU patients. ICU patients had higher BMIs, higher respiratory rates, and lower room-air capillary oxygen saturations. ICU patients showed a more severe inflammatory response as assessed by white blood cell count, neutrophil and platelet count, C-reactive protein, ferritin, procalcitonin, and albumin levels. By the end of the study period, 65 inpatients had been discharged because of improvement, 70 continued hospitalized, and five had died. CONCLUSIONS: Patients with comorbidities, either middle-age obese or elderly complaining of fever, cough, or dyspnea, were more likely to be admitted. At admission, patients with diabetes, high BMI, and clinical or laboratory findings consistent with a severe inflammatory state were more likely to require IC.
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