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  • Title: Immunohistological detection of interleukin I-like molecules and tumour necrosis factor in human epidermis before and after UVB-irradiation in vivo.
    Author: Oxholm A, Oxholm P, Staberg B, Bendtzen K.
    Journal: Br J Dermatol; 1988 Mar; 118(3):369-76. PubMed ID: 3258527.
    Abstract:
    Skin biopsies from five healthy subjects, taken before and after UVB irradiation, were examined using immunohistological techniques for the cytokines interleukin-I (IL-I) and tumour necrosis factor (TNF). Using polyclonal specific antibodies against IL-I and TNF, the two cytokines appeared identically located on the epidermal cell membranes of the stratum granulosum and stratum spinosum in unexposed skin. After UVB-exposure, the staining intensity for both IL-I/epidermal cell derived thymocyte-activating factor (ETAF) and TNF was markedly increased, and the epidermal staining included the basal cell layer. Immunohistological investigation of tissue-bound epidermal cytokines may be valuable in the study of skin diseases.
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