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  • Title: Merger of C-F and C-N Bond Cleavage in Cross-Electrophile Coupling for the Synthesis of gem-Difluoroalkenes.
    Author: Jin Y, Wu J, Lin Z, Lan Y, Wang C.
    Journal: Org Lett; 2020 Jul 17; 22(14):5347-5352. PubMed ID: 32589040.
    Abstract:
    Herein we successfully applied Katritzky salts as the alkyl electrophile in the reductive allylic defluorinative cross-coupling reaction with α-trifluoromethyl alkenes. The merger of C-F and C-N bond cleavage via the synergistic effect of nickel and zinc allows the efficient synthesis of diverse gem-difluoroalkenes with a good tolerance for various functional groups.
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