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  • Title: [Modifications in the urinary excretion of gamma-carboxyglutamic acid induced by vitamin K].
    Author: Werlen D, Robert D, Leclerq M, Guelpa G, Pfister CE.
    Journal: Schweiz Med Wochenschr; 1988 Feb 13; 118(6):203-5. PubMed ID: 3259010.
    Abstract:
    To evaluate urinary GLA excretion, a marker of vitamin K metabolism, the effect of an oral calcium load was studied in 8 volunteers under three conditions: (1) after 1.5 g elementary calcium (calcium carbonate), (2) after 1.5 g calcium (Ossopan, a preparation containing 1 mg osteocalcin per g) and (3) after 1.5 g calcium but with pretreatment of 10 mg vitamin K1 orally for 3 days. No differences in blood calcium, osteocalcin concentration of calciuria were observed. However, GLA excretion was significantly higher with Ossopan or after pretreatment with vitamin K1.
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