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  • Title: Propofol in elderly high risk patients. A comparison of haemodynamic effects with thiopentone during induction of anaesthesia.
    Author: Steib A, Freys G, Beller JP, Curzola U, Otteni JC.
    Journal: Anaesthesia; 1988 Mar; 43 Suppl():111-4. PubMed ID: 3259088.
    Abstract:
    Twenty elderly patients of ASA grade 3 or 4, received either propofol 1 mg/kg or thiopentone 2 mg/kg for induction of anaesthesia. These doses provided a convenient level of anaesthesia for all patients. There were no significant intra- or intergroup haemodynamic changes, with the exception of a decrease in diastolic pressure and rate-pressure product after propofol. It is concluded that propofol 1 mg/kg can be used to induce anaesthesia in elderly high risk patients without deleterious cardiovascular effects.
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