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  • Title: The effects of recombinant CSF-1 on the blast cells of acute myeloblastic leukemia in suspension culture.
    Author: Miyauchi J, Wang C, Kelleher CA, Wong GG, Clark SC, Minden MD, McCulloch EA.
    Journal: J Cell Physiol; 1988 Apr; 135(1):55-62. PubMed ID: 3259237.
    Abstract:
    Recombinant hemopoietic colony-stimulating factors (CSFs), including GM-CSF, G-CSF and IL-3, have been shown to be effective stimulators of both self-renewal and terminal differentiation of blast stem cells in acute myeloblastic leukemia (AML). We have examined the activity of a fourth growth factor, recombinant CSF-1 (or M-CSF), on the growth of leukemic blasts in culture. CSF-1 was found to be active on some, but not all, blast populations. In sensitive cells, CSF-1 often stimulated the production of adherent blast cells incapable of division. This observation leads us to suggest that CSF-1 may be useful in the treatment of selected cases of AML.
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