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  • Title: 99mTc-mercaptoacetyltriglycine Cortical Renography Predicts Outcomes in Adult Living Donor Renal Transplant Recipients.
    Author: Kobayashi T, Nakamoto Y, Sunada T, Sawada A, Yamasaki T, Ogawa O.
    Journal: Transplant Proc; 2020 Dec; 52(10):3090-3096. PubMed ID: 32605777.
    Abstract:
    BACKGROUND: The clinical utility of 99mTc-mercaptoacetyltriglycine cortical renography for the prediction of graft function in kidney transplant recipients has been unknown. METHODS: We retrospectively reviewed post-transplant cortical renograms in 40 kidney transplant recipients. We analyzed the correlation between T1/2 (elimination half-life) and graft function (measured-to-expected glomerular filtration rate [GFR]) 1 week, and 1, 3, and 6 months post operation compared with whole-kidney renograms. RESULTS: Delayed drainage (T1/2 > 11 minutes) was observed in 22 recipients (55%). T1/2 and postoperative GFR ratio were inversely correlated (1 week: R2 = 0.317, P = .0002; 1 month: R2 = 0.206, P = .003; 3 months: R2 = 0.117, P = .031; 6 months: R2 = 0.161, P = .010). Recipients with delayed drainage had a significantly lower GFR ratio than those with normal drainage 1 week (median, 0.93 vs 1.32; P = .001), 1 month (median, 1.65 vs 2.23; P = .0010), 3 months (median, 1.55 vs 2.17; P = .041), and 6 months (median, 1.67 vs 2.34; P = .018) post operation, respectively. Whole-kidney renograms failed to discriminate recipients with lower GFR ratio at 1, 3, and 6 months. CONCLUSIONS: T1/2 in post-transplant cortical renography was inversely correlated with early graft function and may predict early post-transplant graft function.
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