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  • Title: In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole.
    Author: Caputo O, Grosa G, Balliano G, Rocco F, Biglino G.
    Journal: Eur J Drug Metab Pharmacokinet; 1988; 13(1):47-51. PubMed ID: 3260865.
    Abstract:
    The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.
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