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  • Title: Peroperative infusion of dextran 70 and dextran 40 in the prevention of postoperative deep venous thrombosis as confirmed by the I-125-labelled fibrinogen uptake method.
    Author: Huttunen H, Mattila MA, Alhava EM, Kettunen K, Karjalainen P, Poikolainen P, Huttunen K.
    Journal: Ann Chir Gynaecol; 1977; 66(2):79-81. PubMed ID: 326133.
    Abstract:
    The antithrombotic effect of dextran 70 and dextran 40 was studied by a double blind trial in 235 patients with major or medium sized elective procedures. 6% dextran 70 (Macrodex) or 10% dextran 40 (Rhemacrodex) or 5% dextrose in 0.9% saline were given in a double blind manner in 500 ml quantities over 30 minutes starting with the induction of anaesthesia. The diagnosis of deep venous thrombosis was confirmed objectively by the I-125-labelled fibrinogen uptake method. Statistically significant differences in the incidence of deep venous thrombosis between the controls and the dextran groups were not found.
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