These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Stimulated limbic and striatal dopamine release measured by fast cyclic voltammetry: anatomical, electrochemical and pharmacological characterisation.
    Author: Stamford JA, Kruk ZL, Millar J.
    Journal: Brain Res; 1988 Jun 28; 454(1-2):282-8. PubMed ID: 3261616.
    Abstract:
    Fast cyclic voltammetry at carbon fibre microelectrodes was used to monitor stimulated release of electroactive species simultaneously in both caudate and nucleus accumbens. The released species was identified as dopamine in both nuclei on the basis of anatomical, electrochemical and pharmacological criteria. Dopamine release in the nucleus accumbens was consistently evoked at more ventromedial stimulation sites than for caudate. In both nuclei, release was reduced or abolished by alpha-methyl-p-tyrosine and Ro 4-1284. Pargyline, cocaine and GBR 12909 potentiated release while desipramine had no effect. In conjunction with the electrochemical data, the results indicate that dopamine is the sole species detected in caudate and accumbens following stimulation of the median forebrain bundle.
    [Abstract] [Full Text] [Related] [New Search]