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  • Title: Impacts of CD152 polymorphisms on cervical cancer susceptibility.
    Author: Cao S, Zheng L.
    Journal: Pathol Res Pract; 2020 Aug; 216(8):152918. PubMed ID: 32616425.
    Abstract:
    AIM: The objective of this study was to discuss the effect of CD152 polymorphisms rs231775, rs3087243 and rs5742909 on the susceptibility to cervical cancer. METHODS: The databases of PubMed, EMBASE, Cochrane Library, ISI Web of Science, Google Scholar Web, CNKI and Wanfang were searched for eligible studies. Chi-square-based Q test examined heterogeneity between included studies, and when Pheterogeneity was less than 0.05, random-effect model was used to calculate odds ratios (ORs) with their 95 % confidence intervals (95 % CIs); or else, fixed-effect model was selected. Sensitivity analysis was implemented to determine the stability of final results through removing enrolled studies one at a time and then re-obtaining overall estimates. Publication bias among included studies was checked employing Begg's funnel plot and Egger's test. RESULTS: CD152 polymorphism rs231775 decreased cervical cancer risk in total analysis under the genetic models of GG vs. AA, GG vs. AA + AG and G vs. A (OR = 0.73, 95 % CI = 0.59-0.91; OR = 0.78, 95 % CI = 0.65-0.94; OR = 0.92, 95 % CI = 0.87-0.98), and so did the polymorphism rs3087243 in total analysis under the comparisons of AA vs. GG, AA + GA vs. GG, AA vs. GG + GA, A vs. G and GA vs. GG (OR = 0.51, 95 % CI = 0.42-0.60; OR = 0.71, 95 % CI = 0.62-0.82; OR = 0.57, 95 % CI = 0.50-0.66; OR = 0.70, 95 % CI = 0.64-0.77; OR = 0.83, 95 % CI = 0.72-0.97). Besides, the polymorphism rs5742909 elevated the disease onset in total analysis under the contrasts of TT vs. CC, TT + CT vs. CC, TT vs. CC + CT, T vs. C and CT vs. CC (OR = 2.66, 95 % CI = 1.75-4.04; OR = 1.54, 95 % CI = 1.24-1.91; OR = 2.13, 95 % CI = 1.12-4.03; OR = 1.44, 95 % CI = 1.17-1.78; OR = 1.49, 95 % CI = 1.22-1.83). CONCLUSION: CD152 polymorphisms rs231775 and rs3087243 significantly decrease the risk of cervical cancer, while rs5742909 may increase the disease risk.
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