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  • Title: Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.
    Author: Wu YR, Chang KH, Chao CY, Lin CH, Chen YC, Liu TW, Lee-Chen GJ, Chen CM.
    Journal: J Formos Med Assoc; 2021 Jan; 120(1 Pt 2):501-507. PubMed ID: 32620460.
    Abstract:
    BACKGROUND: Oxidative stress could participate in the pathogenesis of Parkinson's disease (PD). However, the role of genetic variation of superoxide dismutase 2 (SOD2), an important regulator against oxidative stress, in PD remains to be elucidated. METHODS: We screened SOD2 gene variation by sequencing cDNA from 72 patients with early onset PD. A cohort of PD (n = 609) and ethnically matched controls (n = 681) were further examined for the identified sequence variant by PCR and NaeI restriction analysis. RESULTS: Only a reported c.47T>C polymorphism (rs4880, SOD2 p.V16A) was found by cDNA sequencing. Case-control study of c.47T>C revealed that genotype and allele frequencies were in Hardy-Weinberg equilibrium in both patients and healthy controls. In a recessive model, those with CC genotype had a 2.61-fold increased risk of PD (95% CI: 1.08-6.30, P = 0.03) compared to subjects with TT and TC genotypes. Significant association between CC genotype and PD in non-smokers was also observed after stratification according to the history of smoking (3.54-fold increased risk of PD, 95% CI: 1.17-10.72, P = 0.02). Meta-analysis by combining studies of Chinese in China, Singapore, and Taiwan (total 2302 cases and 2029 controls) consistently showed CC genotype with increased risk of PD (OR = 1.77, 95% CI: 1.15-2.71, P = 0.01). CONCLUSION: Our findings demonstrate that SOD2 p.V16A may play a role in the susceptibility of PD in Han Chinese.
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