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  • Title: Calcitonin gene-related peptide relaxed rat tail artery helical strips in vitro in an intracellular calcium-dependent manner.
    Author: Kline L, Pang P.
    Journal: Eur J Pharmacol; 1988 Jun 10; 150(3):233-8. PubMed ID: 3262067.
    Abstract:
    The vasoactive properties of calcitonin gene-related peptide (CGRP) were examined using the helical strip of the rat tail artery as a model. CGRP was found to inhibit norepinephrine-induced contraction but not KCl- or vasopressin-induced contraction. No significant inhibition occurred in either KCl- or norepinephrine-stimulated strips when Ca2+ was added incrementally to otherwise Ca2+-free bathing solution. However, a dose-related inhibition to norepinephrine-stimulated contraction in Ca2+-free bathing solution was observed. This strongly suggests that CGRP exerts its effect by inhibiting the mobilization of intracellular Ca2+.
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