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  • Title: Acute anterior uveitis and HLA-B27 subtypes.
    Author: Derhaag PJ, de Waal LP, Linssen A, Feltkamp TE.
    Journal: Invest Ophthalmol Vis Sci; 1988 Jul; 29(7):1137-40. PubMed ID: 3262094.
    Abstract:
    The tissue antigen HLA-B27 is found in 50% of Dutch acute anterior uveitis (AAU) patients. The prevalence of HLA-B27 in the normal population is only 8%. However, only approximately 1% of HLA-B27+ individuals will develop AAU. Therefore, it is possible that the disease is associated with a particular B27 subtype. We typed lymphocytes of 36 B27+ AAU patients, of which 20 also had ankylosing spondylitis, for three serologically defined B27 subtypes (B27 W, B27 K and B27 non W/non K). These subtypes were normally associated with AAU. The subtype frequencies in the patients suffering from both AAU and AS also showed no preference for a certain subtype. Subtype-specific characteristics of the primary structure of the various B27 subtype molecules therefore cannot be responsible for the disease association.
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